Endocrine Abstracts

Background: Changes in gut hormone levels after laparoscopic sleeve gastrectomy (LSG) has been proposed as a possible mechanism that explains the long-term weight loss and the improvement in glucose homeostasis after bariatric operations. In this prospective study we evaluated the changes in the fasting and postprandial levels of glucagon like peptide-1 (GLP-1), peptide YY (PYY), insulin and glucose during the first postoperative year after LSG.Methods: ...

Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) not only functions as a central glycolytic enzyme but also is implicated in the process of apoptosis and gene transcription moving between the cytosol and nucleus. Oxidative stress modifies the activity of GAPDH.The aim of the study was to determine whether oxidative stress (OS) in diabetics is associated with induction of the apoptotic process and higher GAPDH translocation to the nucleus in PBMCs.<p ...

Introduction: There is indirect evidence of unfavorable effects of parathyroid hormone (PTH) on glucose metabolism. Teriparatide (recombinant human PTH 1-34 - TPTD) has been recently available for the treatment of osteoporosis.Aim: To evaluate the acute and chronic effect of TPTD on blood glucose and insulin levels in women with established osteoporosis.Patients and methods: Twenty-three postmenopausal women with established osteop...

Introduction: Acromegaly is characterized by high cardiovascular morbidity and mortality. Oxidative stress and endothelial dysfunction are underlying mechanisms of atherosclerosis. The aim of this study was to evaluate the blood redox status and endothelial function by means of nitric oxide (NO) levels in patients with acromegaly.Description of methods/design: Total antioxidant capacity (TAC), catalase activity and glutathione concentration (GSH), as mea...